Spicy Cajun Chicken Alfredo

Featured in: Cozy Weeknight Meals

This dish features tender chicken breasts coated in vibrant Cajun seasoning and pan-seared until golden. Served over perfectly cooked fettuccine, it's enveloped in a luscious Alfredo sauce made from butter, garlic, cream, and Parmesan. Accented with smoked paprika and optional chili flakes, the sauce balances creamy richness with a subtle heat. Fresh parsley and extra Parmesan bring bright, savory notes. Ideal for those seeking a comforting yet boldly flavored combination.

Updated on Sat, 15 Nov 2025 15:32:00 GMT
Tender slices of Spicy Cajun Chicken Alfredo over creamy fettuccine, ready to serve with parsley garnish. Save
Tender slices of Spicy Cajun Chicken Alfredo over creamy fettuccine, ready to serve with parsley garnish. | crumbnest.com

A bold, creamy pasta dish featuring tender Cajun-spiced chicken tossed with fettuccine in a rich Alfredo sauce, perfect for spice lovers.

I first made this Spicy Cajun Chicken Alfredo for a family dinner when everyone was craving something cozy yet different. The vibrant Cajun flavor always gets rave reviews, and even picky eaters love the creamy sauce with perfectly cooked pasta.

Ingredients

  • Boneless, skinless chicken breasts: 2 large, for hearty servings
  • Cajun seasoning: 2 tablespoons, adds authentic flavor and kick
  • Olive oil: 1 tablespoon, for sautéing chicken
  • Fettuccine: 340 g (12 oz), the classic pasta choice for Alfredo
  • Unsalted butter: 2 tablespoons, forms the rich sauce base
  • Garlic (minced): 3 cloves, for aromatic depth
  • Heavy cream: 1 cup (240 ml), creates luxurious texture
  • Parmesan cheese (freshly grated): 1 cup (100 g), for cheesy goodness
  • Smoked paprika: 1/2 teaspoon, infuses a subtle smokiness
  • Chili flakes: 1/2 teaspoon (optional), for extra heat
  • Salt and black pepper: to taste, balances flavors
  • Fresh parsley (chopped): 2 tablespoons, used as garnish
  • Extra grated Parmesan cheese: for finishing the dish

Instructions

Cook Fettuccine:
Boil fettuccine in salted water according to package instructions until al dente. Reserve 1/2 cup pasta water, drain, and set aside.
Prepare Chicken:
Pat chicken breasts dry and evenly coat with Cajun seasoning.
Cook Chicken:
Heat olive oil in a large skillet over medium-high heat. Add chicken and cook 5 (minutes) per side until golden and cooked through. Rest for 5 (minutes), then slice thinly.
Make Alfredo Sauce:
In the same skillet, reduce heat to medium. Add butter and sauté garlic for 1 (minute) until fragrant. Stir in heavy cream, smoked paprika, and chili flakes. Simmer gently then whisk in Parmesan until sauce is smooth. Season with salt and pepper.
Combine Pasta and Sauce:
Toss cooked fettuccine in the Alfredo sauce. Add reserved pasta water a little at a time to reach desired consistency.
Assemble and Serve:
Top pasta with sliced Cajun chicken. Garnish with parsley and extra Parmesan. Serve promptly.
This decadent Spicy Cajun Chicken Alfredo features golden, spiced chicken sitting next to rich pasta. Save
This decadent Spicy Cajun Chicken Alfredo features golden, spiced chicken sitting next to rich pasta. | crumbnest.com

Gathering everyone around the table for this pasta always sparks laughter and conversation & it's become a go-to comfort dish for busy weeknights and weekend get-togethers.

Required Tools

You will need a large pot for boiling pasta, a large skillet for cooking the chicken and sauce, tongs for tossing, a chef's knife, cutting board, and measuring cups and spoons for accuracy.

Allergen Information

This dish contains dairy (cream, butter, Parmesan), gluten (fettuccine), and may include allergens found in Cajun seasoning. Always verify spice blends for potential cross-contamination.

Nutritional Information

Each serving contains approximately 610 calories, 27 g total fat, 54 g carbohydrates, and 38 g protein.

A steaming bowl of Spicy Cajun Chicken Alfredo, a flavorful, creamy pasta dish with a kick. Save
A steaming bowl of Spicy Cajun Chicken Alfredo, a flavorful, creamy pasta dish with a kick. | crumbnest.com

Cajun Chicken Alfredo is best enjoyed fresh - serve it hot and creamy right out of the pan for maximum flavor. Leftovers reheat beautifully for a quick meal the next day.

Recipe FAQ

How do I ensure the chicken stays juicy?

Pat the chicken dry before seasoning and avoid overcooking. Rest it after cooking to retain juices before slicing.

Can I use a different pasta type?

Yes, penne or linguine work well as alternatives, holding the sauce similarly to fettuccine.

How can I adjust the spice level?

Increase Cajun seasoning or add more chili flakes for extra heat, or reduce for milder flavor.

What thickens the Alfredo sauce naturally?

Butter, heavy cream, and grated Parmesan combine to create a smooth, creamy texture without added thickeners.

How to get a silkier sauce consistency?

Reserve some pasta water and add gradually while tossing pasta in the sauce to achieve a silky finish.

Spicy Cajun Chicken Alfredo

Tender Cajun-seasoned chicken atop fettuccine tossed in a rich, creamy Alfredo sauce with a hint of spice.

Prep duration
15 min
Cook duration
25 min
Complete duration
40 min
Created by Chloe Martin


Skill Level Medium

Heritage American

Output 4 Portions

Dietary considerations None specified

Components

Chicken

01 2 large boneless, skinless chicken breasts
02 2 tablespoons Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 ounces fettuccine

Alfredo Sauce

01 2 tablespoons unsalted butter
02 3 cloves garlic, minced
03 1 cup heavy cream
04 1 cup freshly grated Parmesan cheese
05 1/2 teaspoon smoked paprika
06 1/2 teaspoon chili flakes (optional)
07 Salt and black pepper, to taste

Garnishes

01 2 tablespoons chopped fresh parsley
02 Extra grated Parmesan cheese

Directions

Phase 01

Cook Pasta: Boil salted water and cook fettuccine until al dente according to package directions. Reserve 1/2 cup pasta water, then drain and set aside.

Phase 02

Prepare Chicken: Pat chicken breasts dry and coat evenly with Cajun seasoning.

Phase 03

Cook Chicken: Heat olive oil in a large skillet over medium-high heat. Cook chicken 5-6 minutes per side until cooked through and golden. Remove, rest 5 minutes, then slice thinly.

Phase 04

Sauté Garlic: Reduce skillet heat to medium and add butter. Sauté minced garlic for 1 minute until fragrant.

Phase 05

Prepare Sauce: Add heavy cream, smoked paprika, and chili flakes to skillet. Bring to gentle simmer, then whisk in Parmesan until melted and smooth. Season with salt and pepper.

Phase 06

Combine Pasta and Sauce: Add cooked fettuccine to sauce and toss to coat. Add reserved pasta water gradually if sauce needs thinning.

Phase 07

Serve: Top pasta with sliced Cajun chicken. Garnish with chopped parsley and extra Parmesan. Serve immediately.

Tools needed

  • Large pot
  • Large skillet
  • Tongs
  • Chef's knife
  • Cutting board
  • Measuring cups and spoons

Allergy details

Review each component for potential allergens and seek medical guidance if you're uncertain about ingredients.
  • Contains dairy (cream, butter, Parmesan)
  • Contains gluten (fettuccine)
  • May contain allergens in Cajun seasoning such as mustard or celery

Nutritional information (each portion)

These values are approximate guides only and shouldn't replace professional medical consultation.
  • Energy: 610
  • Fats: 27 g
  • Carbohydrates: 54 g
  • Proteins: 38 g