Alfredo Chicken Zucchini Casserole

Featured in: Cozy Weeknight Meals

Tender chicken breast, fresh zucchini, and savory aromatics are layered with creamy Alfredo sauce, sour cream, and two cheeses for a golden, bubbling main dish. Simply sauté vegetables, mix with chicken and flavorful sauce, top with mozzarella and Parmesan, then bake until the cheese melts and turns golden. Enjoy a low carb, gluten-free-friendly option that suits weeknight dinners and meal prepping, best served with a crisp green salad or crusty bread.

Updated on Sat, 25 Oct 2025 11:27:59 GMT
Golden Alfredo Chicken Zucchini Casserole, bubbling hot from oven, cheesy and fragrant. Save
Golden Alfredo Chicken Zucchini Casserole, bubbling hot from oven, cheesy and fragrant. | crumbnest.com

This Alfredo Chicken Zucchini Casserole is the kind of comfort food I rely on when the week is busy but I still want something cozy and wholesome for dinner. It wraps together juicy chicken, tender zucchini, and a creamy Alfredo sauce under a bubbly, golden cheese topping. With minimal prep and a bake time just long enough to fill your kitchen with delicious smells, this casserole makes weeknights feel special.

On busy nights this casserole saves me so much time and stress. My kids do not even notice there are extra veggies tucked in which makes it a real win at our house.

Ingredients

  • Cooked chicken breast: cubed or shredded Choose free-range if possible The flavor and texture really shine in this casserole
  • Fresh zucchini: sliced The fresher zucchini are the sweeter and more tender they will be at baking time
  • Small onion: finely chopped Adds depth and a soft savory base Look for firm onions with shiny skin
  • Garlic cloves: minced Fresh garlic brings punch Find heads that are plump and free of green shoots
  • Alfredo sauce: either store-bought or homemade Creamy sauce is the soul of this dish Double check labels if you need gluten-free
  • Sour cream: Adds an extra tang and creaminess Choose full-fat for best texture
  • Shredded mozzarella cheese: Melts into a gooey blanket over everything
  • Parmesan cheese: grated Gives sharpness and a golden crust
  • Dried Italian herbs: This touches the casserole with a classic herbal warmth Make your own mix for extra freshness
  • Salt and black pepper: Enhances all the other flavors
  • Chopped fresh parsley: as garnish Brings color and a bright finish Flat-leaf parsley has the best flavor
  • Optional mushrooms or spinach: boosts veggies and flavor

Instructions

Preheat and Prepare the Dish:
Preheat your oven to 375 degrees Fahrenheit or 190 degrees Celsius Lightly grease a standard 9 by 13 inch casserole pan so the casserole will lift out cleanly when served
Build the Sautéed Base:
Set a large skillet on medium heat Drizzle in a touch of olive oil Add your chopped onion and stir for around three minutes until it turns translucent Lower heat if the edges darken These soft onions make a sweet foundation Add minced garlic and gently sauté for another minute until it smells fragrant but does not brown
Prep the Zucchini:
Drop in your sliced zucchini and raise heat to medium Stir every so often so the slices cook evenly For about five minutes cook just until they are tender to the bite but not completely soft You want them to hold their shape in the bake Remove skillet from heat
Mix Everything Together:
Spoon the cooked chicken together with the sautéed veggies into a large mixing bowl Pour in your Alfredo sauce and dollops of sour cream Sprinkle over the dried Italian herbs salt and pepper Use a spatula to fold the mixture gently so the chicken stays chunky and the vegetables do not break down
Assemble the Casserole:
Spread this mixture into your prepared casserole dish in an even layer Make sure every corner is filled Sprinkle the mozzarella evenly over the top followed by all the grated Parmesan cheese
Bake Until Bubbling:
Slide your dish into the preheated oven Bake uncovered for about twenty five to thirty minutes You are looking for the sauce to bubble around the sides and for the top to go golden brown If you like the cheese extra crispy switch on your broiler for two minutes at the end but watch closely
Rest and Finish:
Once out of the oven let the casserole rest for five minutes The sauce thickens and flavors settle Sprinkle with fresh chopped parsley before slicing and serving
Creamy Alfredo Chicken Zucchini Casserole: Layers of cheesy goodness, chicken, zucchini, ready to serve. Save
Creamy Alfredo Chicken Zucchini Casserole: Layers of cheesy goodness, chicken, zucchini, ready to serve. | crumbnest.com

One of my favorite things about this dish is the way the zucchini gets almost buttery under the Alfredo sauce. My sister and I have made this casserole together every year for a family birthday and it is always the first dish to disappear from the table.

Storage Tips

This casserole stores beautifully in the fridge for up to three days Use an airtight container so it stays creamy To reheat just cover and warm through in a low oven or in the microwave If you notice any liquid separation on reheating just give a quick stir and all the creaminess comes right back

Ingredient Substitutions

If you are out of zucchini try yellow squash or eggplant sliced in the same way Swap the chicken for leftover roasted turkey or even cooked shrimp For a different sauce twist pesto or a tomato cream sauce work well and bring in new flavors

Serving Suggestions

Serve this casserole with a big green salad tossed in a simple vinaigrette For a gluten-free meal skip bread and serve with steamed asparagus or sautéed green beans If you have garlic bread lovers in your home it is the perfect companion for mopping up extra sauce

Cultural and Historical Context

This recipe is a play on American casseroles which use whatever is on hand and bring people together with minimal fuss Marrying creamy Alfredo sauce with zucchini and chicken creates a comforting dinner that also fits a lighter modern diet It is ideal for late summer when zucchini is at its peak but feels special enough for a winter table too

Seasonal Adaptations

Use summer squash or pattypan in the hot months Try adding roasted red pepper bits in fall for sweetness Pile on extra spinach in spring for a fresher twist

Success Stories

A friend told me she made this for a new neighbor and ended up getting the recipe request in return I have taken it to potlucks where it vanishes before anything else People love the balance of hearty but not heavy

Freezer Meal Conversion

This casserole can be assembled and frozen before baking Cover tightly in foil and freeze up to two months Thaw in the fridge overnight then bake as directed Add ten extra minutes to the oven time and check for bubbling edges to know it is done

Homemade Alfredo Chicken Zucchini Casserole baked until golden, inviting weeknight meal. Save
Homemade Alfredo Chicken Zucchini Casserole baked until golden, inviting weeknight meal. | crumbnest.com

If you need dinner that feels like a special treat but comes together with pantry and fridge staples this is the one I turn to most often My biggest tip Do not skimp on the cheese layer That finish is what gets everyone racing to the table

Recipe FAQ

Can I use turkey instead of chicken?

Yes, you can substitute cooked turkey for chicken breast for a similar taste and texture.

How can I make this dish gluten-free?

Ensure your Alfredo sauce is gluten-free, and double-check all labels as some sauces may contain wheat.

What other vegetables can I add?

Feel free to include sliced mushrooms or fresh baby spinach for added nutrition and variety.

Which cheese works best for the topping?

Mozzarella offers a gooey texture, while Parmesan gives a salty crunch. You can combine both for best results.

What's the ideal side dish for this casserole?

A crisp green salad or slices of crusty bread complement the rich flavors and creamy texture.

Can I prepare this meal ahead?

Yes, assemble in advance and refrigerate. Bake when needed for a quick weeknight dinner.

Alfredo Chicken Zucchini Casserole

Creamy chicken and zucchini casserole baked with Alfredo sauce, herbs, and cheese for a cozy dinner option.

Prep duration
20 min
Cook duration
35 min
Complete duration
55 min
Created by Chloe Martin


Skill Level Easy

Heritage American/Italian-inspired

Output 4 Portions

Dietary considerations No Gluten, Low-Carbohydrate

Components

Proteins

01 2 cups cooked chicken breast, cubed or shredded (about 2 medium chicken breasts)

Vegetables

01 3 medium zucchinis, sliced into 1/4-inch rounds
02 1 small onion, finely chopped
03 2 cloves garlic, minced

Sauce

01 1 1/2 cups Alfredo sauce (store-bought or homemade; gluten-free if needed)
02 1/2 cup sour cream

Cheese

01 1 cup shredded mozzarella cheese
02 1/2 cup grated Parmesan cheese

Seasonings

01 1/2 teaspoon dried Italian herbs
02 1/4 teaspoon salt
03 1/4 teaspoon black pepper

Optional Garnish

01 2 tablespoons chopped fresh parsley

Directions

Phase 01

Oven Preparation: Preheat oven to 375°F. Lightly coat a 9x13-inch casserole dish with cooking spray or oil.

Phase 02

Sauté Aromatics: Heat a large skillet over medium heat. Add a splash of olive oil. Sauté chopped onion for 3 minutes until translucent, then add minced garlic and cook for 1 minute.

Phase 03

Cook Zucchini: Add zucchini slices to the skillet and sauté for 5 minutes, stirring occasionally, until just tender. Remove from heat to avoid overcooking.

Phase 04

Combine Ingredients: In a large mixing bowl, gently mix cooked chicken, sautéed vegetables, Alfredo sauce, sour cream, dried Italian herbs, salt, and pepper until well combined.

Phase 05

Layer and Top: Transfer the mixture evenly into the prepared casserole dish. Sprinkle shredded mozzarella and grated Parmesan cheese over the surface.

Phase 06

Bake: Bake uncovered for 25–30 minutes until the dish is bubbling and the cheese has turned golden brown.

Phase 07

Rest and Garnish: Allow the casserole to rest for 5 minutes after removing from the oven. Sprinkle chopped parsley over the top before serving.

Tools needed

  • 9x13-inch casserole dish
  • Large skillet
  • Mixing bowl
  • Chef’s knife
  • Cutting board
  • Wooden spoon or spatula

Allergy details

Review each component for potential allergens and seek medical guidance if you're uncertain about ingredients.
  • Contains dairy: Alfredo sauce, sour cream, mozzarella, Parmesan cheese.
  • Verify Alfredo sauce for gluten if sensitive.
  • Contains milk proteins; check all labels for potential additives and hidden allergens.

Nutritional information (each portion)

These values are approximate guides only and shouldn't replace professional medical consultation.
  • Energy: 410
  • Fats: 25 g
  • Carbohydrates: 10 g
  • Proteins: 36 g